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Of Notice is the fact, resulting from PEA’s high lipophilicity, micronized or extremely-micronized formulations are thought being a lot more very easily absorbable, with more favorable pharmacokinetics and increased efficacy. While there is some evidence supporting this concept, there remains no proof of the superiority of micronized PEA [sixteen
Central administration of palmitoylethanolamide minimizes hyperalgesia in mice by using inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolComprehension of exogenous PEA pharmacokinetics is still at an early stage [212]. Upcoming research should really assess the specific tissue distribution and site of metabolism of P
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